Adiponectin regulates AQP3 via PPARα in human hepatic stellate cells.
Biochem Biophys Res Commun
; 490(1): 51-54, 2017 08 12.
Article
en En
| MEDLINE
| ID: mdl-28595905
ABSTRACT
Aquaporins (AQPs) are trans-membrane proteins which allow the movement of water and glycerol required by hepatic stellate cells (HSC) for triglyceride formation and lipid storage. Adiponectin (ADPQ) is a hormone produced by the adipose tissue, which is known to increase AQP3 expression. Since ADPQ receptor signals via the nuclear receptor PPAR we aimed to explore the role of this pathway in AQP3 regulation by ADPQ in HSC. AQP3 and CPT1α expression increased only after ADPQ but not rosiglitazone stimulation. In LX2 cells co-transfected with plasmids expressing PPARα or PPARγ coupled to a luciferase reporter gene, only PPARα increased luciferase activity after ADPQ stimulation. Collectively, our findings demonstrate that ADPQ increases AQP3 expression through PPARα-mediated signaling in HSC.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
PPAR gamma
/
Adiponectina
/
Acuaporina 3
/
Células Estrelladas Hepáticas
Límite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2017
Tipo del documento:
Article
País de afiliación:
Austria