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Decreased pro-inflammatory immune responses during recurrent acute HCV infections in HIV co-infected patients.
Hullegie, Sebastiaan J; Arends, Joop E A; Groothuismink, Zwier M A; Pas, Suzan D; Rijnders, Bart J A; Boonstra, Andre; Claassen, Mark A A.
Afiliación
  • Hullegie SJ; Department of Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands.
  • Arends JEA; Department of Infectious Diseases, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Groothuismink ZMA; Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands.
  • Pas SD; Department of Virology, Erasmus MC, Rotterdam, The Netherlands.
  • Rijnders BJA; Department of Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands.
  • Boonstra A; Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands.
  • Claassen MAA; Department of Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands.
J Gen Virol ; 98(6): 1294-1298, 2017 Jun.
Article en En | MEDLINE | ID: mdl-28597817
Patients in high-risk groups continue to transmit the hepatitis C virus (HCV) and frequently experience reinfections. Since little is known regarding the immune response to HCV during reinfection, we compared primary and consecutive acute HCV infections in patients with an HIV infection, and focused on the cytokine bridging innate to adaptive immunity. We observed that the serum levels of IL-12p40, MIP-1ß, MIG and IP-10 increased during primary acute HCV infection, but not during subsequent secondary acute reinfections. The weaker pro-inflammatory cytokine responses observed during HCV reinfections suggest more limited secondary acute immune responses, which may prevent damage to the infected liver.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infecciones por VIH / Citocinas / Hepatitis C / Hepacivirus / Coinfección Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Gen Virol Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infecciones por VIH / Citocinas / Hepatitis C / Hepacivirus / Coinfección Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Gen Virol Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos