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Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation.
Samadder, Pounami; Suchánková, Tereza; Hylse, Ondrej; Khirsariya, Prashant; Nikulenkov, Fedor; Drápela, Stanislav; Straková, Nicol; Vanhara, Petr; Vasícková, Katerina; Kolárová, Hana; Binó, Lucia; Bittová, Miroslava; Ovesná, Petra; Kollár, Peter; Fedr, Radek; Esner, Milan; Jaros, Josef; Hampl, Ales; Krejcí, Lumír; Paruch, Kamil; Soucek, Karel.
Afiliación
  • Samadder P; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
  • Suchánková T; National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic.
  • Hylse O; International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne's University Hospital in Brno, Brno, Czech Republic.
  • Khirsariya P; Department of Cytokinetics, Institute of Biophysics CAS, Brno, Czech Republic.
  • Nikulenkov F; Department of Chemistry, CZ Openscreen, Faculty of Science, Masaryk University, Brno, Czech Republic.
  • Drápela S; International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne's University Hospital in Brno, Brno, Czech Republic.
  • Straková N; Department of Chemistry, CZ Openscreen, Faculty of Science, Masaryk University, Brno, Czech Republic.
  • Vanhara P; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
  • Vasícková K; International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne's University Hospital in Brno, Brno, Czech Republic.
  • Kolárová H; Department of Cytokinetics, Institute of Biophysics CAS, Brno, Czech Republic.
  • Binó L; International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne's University Hospital in Brno, Brno, Czech Republic.
  • Bittová M; Department of Cytokinetics, Institute of Biophysics CAS, Brno, Czech Republic.
  • Ovesná P; International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne's University Hospital in Brno, Brno, Czech Republic.
  • Kollár P; Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic.
  • Fedr R; International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne's University Hospital in Brno, Brno, Czech Republic.
  • Esner M; Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic.
  • Jaros J; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
  • Hampl A; National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic.
  • Krejcí L; International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne's University Hospital in Brno, Brno, Czech Republic.
  • Paruch K; International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne's University Hospital in Brno, Brno, Czech Republic.
  • Soucek K; Department of Cytokinetics, Institute of Biophysics CAS, Brno, Czech Republic.
Mol Cancer Ther ; 16(9): 1831-1842, 2017 09.
Article en En | MEDLINE | ID: mdl-28619751
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Resistencia a Antineoplásicos / Inhibidores de Proteínas Quinasas / Quinasa 1 Reguladora del Ciclo Celular (Checkpoint 1) / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Mol Cancer Ther Asunto de la revista: ANTINEOPLASICOS Año: 2017 Tipo del documento: Article País de afiliación: República Checa
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Resistencia a Antineoplásicos / Inhibidores de Proteínas Quinasas / Quinasa 1 Reguladora del Ciclo Celular (Checkpoint 1) / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Mol Cancer Ther Asunto de la revista: ANTINEOPLASICOS Año: 2017 Tipo del documento: Article País de afiliación: República Checa