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Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
Lorthiois, Edwige; Anderson, Karen; Vulpetti, Anna; Rogel, Olivier; Cumin, Frederic; Ostermann, Nils; Steinbacher, Stefan; Mac Sweeney, Aengus; Delgado, Omar; Liao, Sha-Mei; Randl, Stefan; Rüdisser, Simon; Dussauge, Solene; Fettis, Kamal; Kieffer, Laurence; de Erkenez, Andrea; Yang, Louis; Hartwieg, Constanze; Argikar, Upendra A; La Bonte, Laura R; Newton, Ronald; Kansara, Viral; Flohr, Stefanie; Hommel, Ulrich; Jaffee, Bruce; Maibaum, Jürgen.
Afiliación
  • Lorthiois E; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Anderson K; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Cambridge, Massachusetts 02139, United States.
  • Vulpetti A; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Rogel O; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Cumin F; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Ostermann N; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Steinbacher S; Proteros Biostructures GmbH , D-82152 Planegg-Martinsried, Germany.
  • Mac Sweeney A; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Delgado O; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Cambridge, Massachusetts 02139, United States.
  • Liao SM; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Cambridge, Massachusetts 02139, United States.
  • Randl S; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Rüdisser S; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Dussauge S; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Fettis K; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Kieffer L; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • de Erkenez A; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Cambridge, Massachusetts 02139, United States.
  • Yang L; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Cambridge, Massachusetts 02139, United States.
  • Hartwieg C; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Argikar UA; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Cambridge, Massachusetts 02139, United States.
  • La Bonte LR; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Cambridge, Massachusetts 02139, United States.
  • Newton R; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Cambridge, Massachusetts 02139, United States.
  • Kansara V; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Cambridge, Massachusetts 02139, United States.
  • Flohr S; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Hommel U; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Jaffee B; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Cambridge, Massachusetts 02139, United States.
  • Maibaum J; Novartis Pharma AG, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
J Med Chem ; 60(13): 5717-5735, 2017 07 13.
Article en En | MEDLINE | ID: mdl-28621538
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Prolina / Factor D del Complemento / Vía Alternativa del Complemento Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Prolina / Factor D del Complemento / Vía Alternativa del Complemento Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Suiza