Nerve growth factor and basic fibroblast growth factor promote reinnervation by nerve-muscle-endplate grafting.
Muscle Nerve
; 57(3): 449-459, 2018 03.
Article
en En
| MEDLINE
| ID: mdl-28632904
ABSTRACT
INTRODUCTION:
This study was designed to test whether exogenous application of nerve growth factor (NGF) and basic fibroblast growth factor (FGF-2) to muscles reinnervated with nerve-muscle-endplate band grafting (NMEG) could promote specific outcomes.METHODS:
The right sternomastoid muscle in adult rats was experimentally denervated and immediately reinnervated by implanting an NMEG pedicle from the ipsilateral sternohyoid muscle. A fibrin sealant containing NGF and FGF-2 was focally applied to the implantation site. Maximal tetanic force, muscle weight, regenerated axons, and motor endplates were analyzed 3 months after treatment.RESULTS:
Mean tetanic force, wet muscle weight, and number of regenerated axons in the treated muscles were 91%, 92%, and 84% of the contralateral controls, respectively. The majority of endplates (86%) in the treated muscles were reinnervated by regenerated axons.DISCUSSION:
Focal administration of NGF and FGF-2 promotes efficacy of the NMEG technique. Muscle Nerve 57 449-459, 2018.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Factor 2 de Crecimiento de Fibroblastos
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Músculo Esquelético
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Recuperación de la Función
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Factor de Crecimiento Nervioso
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Placa Motora
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Regeneración Nerviosa
Límite:
Animals
Idioma:
En
Revista:
Muscle Nerve
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos