TIminer: NGS data mining pipeline for cancer immunology and immunotherapy.
Bioinformatics
; 33(19): 3140-3141, 2017 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-28633385
ABSTRACT
SUMMARY:
Recently, a number of powerful computational tools for dissecting tumor-immune cell interactions from next-generation sequencing data have been developed. However, the assembly of analytical pipelines and execution of multi-step workflows are laborious and involve a large number of intermediate steps with many dependencies and parameter settings. Here we present TIminer, an easy-to-use computational pipeline for mining tumor-immune cell interactions from next-generation sequencing data. TIminer enables integrative immunogenomic analyses, including human leukocyte antigens typing, neoantigen prediction, characterization of immune infiltrates and quantification of tumor immunogenicity. AVAILABILITY AND IMPLEMENTATION TIminer is freely available at http//icbi.i-med.ac.at/software/timiner/timiner.shtml. CONTACT zlatko.trajanoski@i-med.ac.at. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Programas Informáticos
/
Secuenciación de Nucleótidos de Alto Rendimiento
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Bioinformatics
Asunto de la revista:
INFORMATICA MEDICA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Austria