Muscle Tissue Saturation Compared With Muscle Tissue Perfusion During Low Blood Flows: An Experimental Study.
J Cardiothorac Vasc Anesth
; 31(6): 2065-2071, 2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-28693932
ABSTRACT
OBJECTIVE:
To investigate whether changes in muscle tissue perfusion measured with positron emission tomography would be reflected by parallel changes in muscle tissue oxygen saturation (StO2) measured using near-infrared spectroscopy during high and low blood flow levels achieved using cardiopulmonary bypass (CPB) in an animal model.DESIGN:
A prospective, randomized study.SETTING:
Research laboratory, single institution.PARTICIPANTS:
Eight pigs (69-71 kg).INTERVENTIONS:
In anesthetized pigs, normothermic CPB was established with a blood flow of 60 mL/kg/min for 1 hour. Thereafter, a low blood flow of either 47.5 or 35 mL/kg/min was applied for 1 hour followed by a blood flow of 60 mL/kg/min for an additional hour. Regional StO2 was measured continuously by placing a near-infrared spectroscopy electrode on the skin above the gracilis muscle of the noncannulated back leg. Muscle tissue perfusion was measured using positron emission tomography with 15O-labeled water during spontaneous circulation and the different CPB blood flows. Systemic oxygen consumption was estimated by measurement of venous saturation and lactate levels. MEASUREMENTS AND MAINRESULTS:
The results showed profound systemic ischemia during low CPB blood flow. StO2 remained high until muscle tissue perfusion decreased to about 50%, after which StO2 paralleled the linear decrease in muscle tissue perfusion.CONCLUSION:
In an experimental CPB animal model, StO2 was stable until muscle tissue perfusion was reduced by about 50%, and at lower blood flow levels, there was almost a linear relationship between StO2 and muscle tissue perfusion.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Consumo de Oxígeno
/
Velocidad del Flujo Sanguíneo
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Puente Cardiopulmonar
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Hemodinámica
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Músculos
Límite:
Animals
Idioma:
En
Revista:
J Cardiothorac Vasc Anesth
Asunto de la revista:
ANESTESIOLOGIA
/
CARDIOLOGIA
Año:
2017
Tipo del documento:
Article