The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK.
Mar Drugs
; 15(8)2017 Aug 07.
Article
en En
| MEDLINE
| ID: mdl-28783126
ABSTRACT
In previous work, we characterized the strong neuroprotective properties of the marine compound Psammaplysene A (PA) in in vitro and in vivo models of neurodegeneration. Based on its strong neuroprotective activity, the current work attempts to identify the physical target of PA to gain mechanistic insight into its molecular action. Two distinct methods, used in parallel, to purify protein-binding partners of PA led to the identification of HNRNPK as a direct target of PA. Based on surface plasmon resonance, we find that the binding of PA to HNRNPK is RNA-dependent. These findings suggest a role for HNRNPK-dependent processes in neurodegeneration/neuroprotection, and warrant further study of HNRNPK in this context.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Tirosina
/
Proteínas de Unión al ARN
/
Fármacos Neuroprotectores
/
Ribonucleoproteína Heterogénea-Nuclear Grupo K
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Mar Drugs
Asunto de la revista:
BIOLOGIA
/
FARMACOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos