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In Vitro Interactions of Echinocandins with Triazoles against Multidrug-Resistant Candida auris.
Fakhim, Hamed; Chowdhary, Anuradha; Prakash, Anupam; Vaezi, Afsane; Dannaoui, Eric; Meis, Jacques F; Badali, Hamid.
Afiliación
  • Fakhim H; Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
  • Chowdhary A; Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.
  • Prakash A; Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
  • Vaezi A; Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
  • Dannaoui E; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
  • Meis JF; Université Paris-Descartes, Faculté de Médecine, APHP, Hôpital Européen Georges Pompidou, Unité de Parasitologie-Mycologie, Service de Microbiologie, Paris, France.
  • Badali H; Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
Antimicrob Agents Chemother ; 61(11)2017 11.
Article en En | MEDLINE | ID: mdl-28848002
ABSTRACT
We determined the in vitro interactions between echinocandins and azoles against 10 multidrug-resistant Candida auris strains by use of a microdilution checkerboard technique. Our results suggest synergistic interactions between micafungin and voriconazole with fractional inhibitory concentration index (FICI) values of 0.15 to 0.5, and we observed indifferent interactions when micafungin was combined with fluconazole (FICI, 0.62 to 1.5). Combinations of caspofungin with fluconazole or voriconazole exhibited indifferent interactions. No antagonism was observed for any combination.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Triazoles / Candida / Farmacorresistencia Fúngica Múltiple / Equinocandinas / Antifúngicos Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2017 Tipo del documento: Article País de afiliación: Irán
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Triazoles / Candida / Farmacorresistencia Fúngica Múltiple / Equinocandinas / Antifúngicos Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2017 Tipo del documento: Article País de afiliación: Irán