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A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
Baker, David A; Stewart, Lindsay B; Large, Jonathan M; Bowyer, Paul W; Ansell, Keith H; Jiménez-Díaz, María B; El Bakkouri, Majida; Birchall, Kristian; Dechering, Koen J; Bouloc, Nathalie S; Coombs, Peter J; Whalley, David; Harding, Denise J; Smiljanic-Hurley, Ela; Wheldon, Mary C; Walker, Eloise M; Dessens, Johannes T; Lafuente, María José; Sanz, Laura M; Gamo, Francisco-Javier; Ferrer, Santiago B; Hui, Raymond; Bousema, Teun; Angulo-Barturén, Iñigo; Merritt, Andy T; Croft, Simon L; Gutteridge, Winston E; Kettleborough, Catherine A; Osborne, Simon A.
Afiliación
  • Baker DA; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. david.baker@lshtm.ac.uk.
  • Stewart LB; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
  • Large JM; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK.
  • Bowyer PW; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
  • Ansell KH; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK.
  • Jiménez-Díaz MB; Tres Cantos Medicines Development Campus-Diseases of the Developing World, GlaxoSmithKline, Tres Cantos,, 28760, Madrid, Spain.
  • El Bakkouri M; Structural Genomics Consortium, University of Toronto, MaRS South Tower, 101 College Street, Toronto, ON, Canada, M5G 1L7.
  • Birchall K; Toronto General Hospital Research Institute, 610 University Avenue, Toronto, ON, Canada, M5G 2M9.
  • Dechering KJ; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK.
  • Bouloc NS; TropIQ Health Sciences, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
  • Coombs PJ; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK.
  • Whalley D; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK.
  • Harding DJ; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK.
  • Smiljanic-Hurley E; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK.
  • Wheldon MC; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK.
  • Walker EM; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK.
  • Dessens JT; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
  • Lafuente MJ; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
  • Sanz LM; Tres Cantos Medicines Development Campus-Diseases of the Developing World, GlaxoSmithKline, Tres Cantos,, 28760, Madrid, Spain.
  • Gamo FJ; Tres Cantos Medicines Development Campus-Diseases of the Developing World, GlaxoSmithKline, Tres Cantos,, 28760, Madrid, Spain.
  • Ferrer SB; Tres Cantos Medicines Development Campus-Diseases of the Developing World, GlaxoSmithKline, Tres Cantos,, 28760, Madrid, Spain.
  • Hui R; Tres Cantos Medicines Development Campus-Diseases of the Developing World, GlaxoSmithKline, Tres Cantos,, 28760, Madrid, Spain.
  • Bousema T; Structural Genomics Consortium, University of Toronto, MaRS South Tower, 101 College Street, Toronto, ON, Canada, M5G 1L7.
  • Angulo-Barturén I; Toronto General Hospital Research Institute, 610 University Avenue, Toronto, ON, Canada, M5G 2M9.
  • Merritt AT; Department of Medical Microbiology, Radboud University Medical Center, 6525 HP, Nijmegen, The Netherlands.
  • Croft SL; Tres Cantos Medicines Development Campus-Diseases of the Developing World, GlaxoSmithKline, Tres Cantos,, 28760, Madrid, Spain.
  • Gutteridge WE; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK.
  • Kettleborough CA; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
  • Osborne SA; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Nat Commun ; 8(1): 430, 2017 09 05.
Article en En | MEDLINE | ID: mdl-28874661
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Piridinas / Proteínas Quinasas Dependientes de GMP Cíclico / Imidazoles / Malaria Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Piridinas / Proteínas Quinasas Dependientes de GMP Cíclico / Imidazoles / Malaria Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido