Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in locomotor and respiratory muscles during experimental sepsis in mice.
Sci Rep
; 7(1): 10866, 2017 09 07.
Article
en En
| MEDLINE
| ID: mdl-28883493
ABSTRACT
Sepsis induced loss of muscle mass and function contributes to promote physical inactivity and disability in patients. In this experimental study, mice were sacrificed 1, 4, or 7 days after cecal ligation and puncture (CLP) or sham surgery. When compared with diaphragm, locomotor muscles were more prone to sepsis-induced muscle mass loss. This could be attributed to a greater activation of ubiquitin-proteasome system and an increased myostatin expression. Thus, this study strongly suggests that the contractile activity pattern of diaphragm muscle confers resistance to atrophy compared to the locomotor gastrocnemius muscle. These data also suggest that a strategy aimed at preventing the activation of catabolic pathways and preserving spontaneous activity would be of interest for the treatment of patients with sepsis-induced neuromyopathy.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Autofagia
/
Transducción de Señal
/
Sepsis
/
Ubiquitina
/
Complejo de la Endopetidasa Proteasomal
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Proteínas Proto-Oncogénicas c-akt
/
Serina-Treonina Quinasas TOR
/
Lisosomas
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Sci Rep
Año:
2017
Tipo del documento:
Article
País de afiliación:
Francia