Biomechanical and Hemodynamic Measures of Right Ventricular Diastolic Function: Translating Tissue Biomechanics to Clinical Relevance.
J Am Heart Assoc
; 6(9)2017 Sep 12.
Article
en En
| MEDLINE
| ID: mdl-28899895
ABSTRACT
BACKGROUND:
Right ventricular (RV) diastolic function has been associated with outcomes for patients with pulmonary hypertension; however, the relationship between biomechanics and hemodynamics in the right ventricle has not been studied. METHODS ANDRESULTS:
Rat models of RV pressure overload were obtained via pulmonary artery banding (PAB; control, n=7; PAB, n=5). At 3 weeks after banding, RV hemodynamics were measured using a conductance catheter. Biaxial mechanical properties of the RV free wall myocardium were obtained to extrapolate longitudinal and circumferential elastic modulus in low and high strain regions (E1 and E2, respectively). Hemodynamic analysis revealed significantly increased end-diastolic elastance (Eed) in PAB (control 55.1 mm Hg/mL [interquartile range 44.7-85.4 mm Hg/mL]; PAB 146.6 mm Hg/mL [interquartile range 105.8-155.0 mm Hg/mL]; P=0.010). Longitudinal E1 was increased in PAB (control 7.2 kPa [interquartile range 6.7-18.1 kPa]; PAB 34.2 kPa [interquartile range 18.1-44.6 kPa]; P=0.018), whereas there were no significant changes in longitudinal E2 or circumferential E1 and E2. Last, wall stress was calculated from hemodynamic data by modeling the right ventricle as a sphere stress=Pressure×radius2×thickness.CONCLUSIONS:
RV pressure overload in PAB rats resulted in an increase in diastolic myocardial stiffness reflected both hemodynamically, by an increase in Eed, and biomechanically, by an increase in longitudinal E1. Modest increases in tissue biomechanical stiffness are associated with large increases in Eed. Hemodynamic measurements of RV diastolic function can be used to predict biomechanical changes in the myocardium.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Función Ventricular Derecha
/
Disfunción Ventricular Derecha
/
Investigación Biomédica Traslacional
/
Ventrículos Cardíacos
/
Hemodinámica
/
Hipertensión Pulmonar
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Am Heart Assoc
Año:
2017
Tipo del documento:
Article
País de afiliación:
Panamá