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The immunology of the allergy epidemic and the hygiene hypothesis.
Lambrecht, Bart N; Hammad, Hamida.
Afiliación
  • Lambrecht BN; VIB Center for Inflammation Research, Ghent University, Ghent, Belgium.
  • Hammad H; Department of Respiratory Medicine, University Hospital Ghent, Ghent, Belgium.
Nat Immunol ; 18(10): 1076-1083, 2017 Sep 19.
Article en En | MEDLINE | ID: mdl-28926539
The immunology of the hygiene hypothesis of allergy is complex and involves the loss of cellular and humoral immunoregulatory pathways as a result of the adoption of a Western lifestyle and the disappearance of chronic infectious diseases. The influence of diet and reduced microbiome diversity now forms the foundation of scientific thinking on how the allergy epidemic occurred, although clear mechanistic insights into the process in humans are still lacking. Here we propose that barrier epithelial cells are heavily influenced by environmental factors and by microbiome-derived danger signals and metabolites, and thus act as important rheostats for immunoregulation, particularly during early postnatal development. Preventive strategies based on this new knowledge could exploit the diversity of the microbial world and the way humans react to it, and possibly restore old symbiotic relationships that have been lost in recent times, without causing disease or requiring a return to an unhygienic life style.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Epidermis / Hipótesis de la Higiene / Hipersensibilidad Límite: Animals / Humans Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Bélgica

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Epidermis / Hipótesis de la Higiene / Hipersensibilidad Límite: Animals / Humans Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Bélgica