Your browser doesn't support javascript.
loading
FOXO1: Another avenue for treating digestive malignancy?
Shi, Feiyu; Li, Tian; Liu, Zhi; Qu, Kai; Shi, Chengxin; Li, Yaguang; Qin, Qian; Cheng, Liang; Jin, Xin; Yu, Tianyu; Di, Wencheng; Que, Jianwen; Xia, Hongping; She, Junjun.
Afiliación
  • Shi F; Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi, China.
  • Li T; Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, Shaanxi, China.
  • Liu Z; Department of Stomatology, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi, China.
  • Qu K; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi, China.
  • Shi C; Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi, China.
  • Li Y; Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi, China.
  • Qin Q; Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi, China.
  • Cheng L; Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi, China.
  • Jin X; Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi, China.
  • Yu T; Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi, China.
  • Di W; Department of Cardiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, Jiangsu, China.
  • Que J; Center for Human Development & Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, 10032, NY, USA.
  • Xia H; Laboratory of Cancer Genomics, National Cancer Centre, Singapore 169610, Singapore.
  • She J; Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi, China. Electronic address: sjuns@sina.com.
Semin Cancer Biol ; 50: 124-131, 2018 06.
Article en En | MEDLINE | ID: mdl-28965871
ABSTRACT
Digestive malignancies are the leading cause of mortality among all neoplasms, contributing to estimated 3 million deaths in 2012 worldwide. The mortality rate hassurpassed lung cancer and prostate cancer in recent years. The transcription factor Forkhead Box O1 (FOXO1) is a key member of Forkhead Box family, regulating diverse cellular functions during tumor initiation, progression and metastasis. In this review, we focus on recent studies investigating the antineoplastic role of FOXO1 in digestive malignancy. This review aims to serve as a guide for further research and implicate FOXO1 as a potent therapeutic target in digestive malignancy.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Carcinogénesis / Proteína Forkhead Box O1 / Neoplasias Gastrointestinales / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Semin Cancer Biol Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Carcinogénesis / Proteína Forkhead Box O1 / Neoplasias Gastrointestinales / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Semin Cancer Biol Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: China