Insights into the role of methionine synthase in the universal <sup>13</sup>C depletion in O- and N-methyl groups of natural products.

Romek, Katarzyna M; Krzeminska, Agnieszka; Remaud, Gérald S; Julien, Maxime; Paneth, Piotr; Robins, Richard J

Insights into the role of methionine synthase in the universal ¹³C depletion in O- and N-methyl groups of natural products.

Romek, Katarzyna M; Krzeminska, Agnieszka; Remaud, Gérald S; Julien, Maxime; Paneth, Piotr; Robins, Richard J.

Afiliación

Romek KM; Elucidation of Biosynthesis by Isotopic Spectrometry Group, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, Centre National de la Recherche Scientifique-University of Nantes, Unité Mixte de Recherche 6230, F-44322 Nantes, France; Institute of Applied Radiation Chemistry, Faculty of Chemi
Krzeminska A; Institute of Applied Radiation Chemistry, Faculty of Chemistry, Lodz University of Technology, ul. Stefana Zeromskiego 116, 90-924 Lódz, Poland.
Remaud GS; Elucidation of Biosynthesis by Isotopic Spectrometry Group, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, Centre National de la Recherche Scientifique-University of Nantes, Unité Mixte de Recherche 6230, F-44322 Nantes, France.
Julien M; Elucidation of Biosynthesis by Isotopic Spectrometry Group, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, Centre National de la Recherche Scientifique-University of Nantes, Unité Mixte de Recherche 6230, F-44322 Nantes, France.
Paneth P; Institute of Applied Radiation Chemistry, Faculty of Chemistry, Lodz University of Technology, ul. Stefana Zeromskiego 116, 90-924 Lódz, Poland.
Robins RJ; Elucidation of Biosynthesis by Isotopic Spectrometry Group, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, Centre National de la Recherche Scientifique-University of Nantes, Unité Mixte de Recherche 6230, F-44322 Nantes, France. Electronic address: richard.robins@univ-nantes.fr.

Arch Biochem Biophys ; 635: 60-65, 2017 12 01.

Article en En | MEDLINE | ID: mdl-29074162

Asunto(s)

5-Metiltetrahidrofolato-Homocisteína S-Metiltransferasa/metabolismo; 5-Metiltetrahidrofolato-Homocisteína S-Metiltransferasa/ultraestructura; Isótopos de Carbono/química; Metionina/química; Nitrógeno/química; Oxígeno/química; Sitios de Unión; Simulación por Computador; Activación Enzimática; Metilación; Modelos Químicos; Modelos Moleculares; Unión Proteica; Especificidad por Sustrato

Palabras clave

(13)C NMR; (13)C/(12)C isotope fractionation; O-methyl and N-methyl groups; QM/MM theoretical calculation; l-methionine; l-methionine synthase (EC 2.1.1.14)

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oxígeno / 5-Metiltetrahidrofolato-Homocisteína S-Metiltransferasa / Isótopos de Carbono / Metionina / Nitrógeno Tipo de estudio: Prognostic_studies Idioma: En Revista: Arch Biochem Biophys Año: 2017 Tipo del documento: Article

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