Sufentanil sublingual tablet 30mcg for moderate-to-severe acute pain in the ED.
Am J Emerg Med
; 36(6): 954-961, 2018 Jun.
Article
en En
| MEDLINE
| ID: mdl-29122372
ABSTRACT
BACKGROUND:
Pharmacological properties of the sufentanil sublingual tablet 30mcg (SST 30mcg) could offer potential analgesic advantages in settings requiring noninvasive, acute pain management. The feasibility of using SST 30mcg for moderate-to-severe pain management in the emergency department (ED) was evaluated.METHODS:
This open-label, multicenter feasibility study included patients aged ≥18years who presented to the ED with moderate-to-severe pain (≥4 on the numeric rating scale of pain intensity (NRS); opioid-tolerant patients were excluded. Patients received a single SST 30-mcg dose (single-dose cohort) or, upon request, ≤3 additional doses ≥60min apart (multiple-dose cohort) and were evaluated over 1 or 2h. Effectiveness was assessed by patient-reported pain scores (11-point NRS; 5-point pain relief scale). Safety and tolerability were also assessed.RESULTS:
Overall, 76 patients enrolled into the single-dose (n=40) and multiple-dose (n=36) cohorts. In the first hour (combined cohorts), mean pain intensity was significantly lower 15-min post-dosing (P<0.001; clinically meaningful within 30-minutes post-dosing) and continued to decrease during the first hour (P<0.001 for each 15-minute interval). Mean pain intensity (multiple-dose cohort) decreased from 7.6 at baseline to 4.5 at 1h and to 4.6 at 2h (P<0.001 for both); mean pain relief increased from baseline to 1.9 at 1h (P<0.001) and to 2.0 at 2h (P<0.001). Most (79%) patients had no adverse events (AEs), and there were no severe AEs.CONCLUSIONS:
SST 30mcg was feasible for managing moderate-to-severe acute pain in an ED setting.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sufentanilo
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Servicio de Urgencia en Hospital
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Dolor Agudo
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Manejo del Dolor
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Am J Emerg Med
Año:
2018
Tipo del documento:
Article