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Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents.
Pagire, Suvarna H; Lee, Eunhye; Pagire, Haushabhau S; Bae, Eun Jung; Ryu, Soo Jung; Lee, Dahye; Kim, Min Hee; Kim, Geum Ran; Hwang, Kyu-Seok; Ahn, Sukyung; Maeng, Jin Hee; Song, Jin Sook; Bae, Myung Ae; Lee, Don Hang; Ahn, Jin Hee.
Afiliación
  • Pagire SH; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
  • Lee E; Utah-Inha Drug Delivery Systems (DDS) and Advanced Therapeutics Research Center, Incheon 21988, Republic of Korea.
  • Pagire HS; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
  • Bae EJ; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
  • Ryu SJ; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
  • Lee D; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
  • Kim MH; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
  • Kim GR; Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea.
  • Hwang KS; Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea.
  • Ahn S; Utah-Inha Drug Delivery Systems (DDS) and Advanced Therapeutics Research Center, Incheon 21988, Republic of Korea.
  • Maeng JH; Utah-Inha Drug Delivery Systems (DDS) and Advanced Therapeutics Research Center, Incheon 21988, Republic of Korea.
  • Song JS; Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea.
  • Bae MA; Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea.
  • Lee DH; Utah-Inha Drug Delivery Systems (DDS) and Advanced Therapeutics Research Center, Incheon 21988, Republic of Korea.
  • Ahn JH; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea. Electronic address: jhahn@gist.ac.kr.
Bioorg Med Chem Lett ; 28(3): 529-532, 2018 02 01.
Article en En | MEDLINE | ID: mdl-29295794
ABSTRACT
A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Picratos / Compuestos de Bifenilo / Diseño de Fármacos / Antiinflamatorios no Esteroideos / Ácido Glutámico / Antioxidantes Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Picratos / Compuestos de Bifenilo / Diseño de Fármacos / Antiinflamatorios no Esteroideos / Ácido Glutámico / Antioxidantes Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article