Rubella natural immunity among adolescent girls in Tanzania: the need to vaccinate child bearing aged women.
BMC Womens Health
; 18(1): 3, 2018 01 03.
Article
en En
| MEDLINE
| ID: mdl-29298693
ABSTRACT
BACKGROUND:
Rubella primary infection during early stages of pregnancy is associated with high risk of congenital Rubella syndrome (CRS). Prevention of CRS in the resource-limited countries requires multiple strategies. Here, we document the data on the magnitude of Rubella natural immunity among adolescent girls which is a crucial group in devising effective control strategies to prevent CRS.METHODS:
A cross sectional study involving 397 adolescent girls was conducted in the city of Mwanza involving five secondary schools. Socio-demographic and other relevant information were collected using pre-tested data collection tool. Rubella IgG antibodies were determined using enzyme immunoassay. The presence of Rubella IgG titers of >10 IU/ml indicated natural immunity.RESULTS:
The mean age of the study participants was 15.18 ± 1.48 years. Of 397 girls, 340 (85.6%) and 57 (14.4%) were from secondary schools representing peri-urban and rural areas, respectively. Out of 397 girls, 90.4% (95% CI 87-93) were found to be naturally immune with median Rubella IgG antibodies titers of 56.7 IU/ml interquartile range (IQR) 40.8-137. The median Rubella IgG antibodies titers were significantly high in adolescent girls from families with high socio-economic status (63.96 vs. 47.13 IU/ml, P < 0.001) and in adolescent girls from peri-urban areas of the city (63.33 vs. 39.9 IU/ml, P < 0.001).CONCLUSION:
The majority of adolescent girls in the city of Mwanza are naturally immune to Rubella virus. There is a need to compare the effectiveness of screening and vaccinating susceptible adolescent girls with the effectiveness of vaccinating all women of childbearing in controlling CRS in low-income countries.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Rubéola (Sarampión Alemán)
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Síndrome de Rubéola Congénita
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Inmunoglobulina G
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Vacunación
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Inmunidad Innata
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Anticuerpos Antivirales
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Adolescent
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Female
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Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
BMC Womens Health
Asunto de la revista:
SAUDE DA MULHER
Año:
2018
Tipo del documento:
Article
País de afiliación:
Tanzania