2-(2-Nitrovinyl) furan exacerbates oxidative stress response of Escherichia coli to bacteriostatic and bactericidal antibiotics.
Microb Pathog
; 116: 130-134, 2018 Mar.
Article
en En
| MEDLINE
| ID: mdl-29325866
ABSTRACT
The influence of 2-(2-nitrovinyl) furan on the activities of selected bacteriostatic and bactericidal antibiotics was investigated. Minimum inhibitory concentration and fractional inhibitory concentration index were determined to evaluate the interaction between 2-(2-nitrovinyl) furan and the antibiotics. 2-(2-nitrovinyl) furan exhibited additive interactions with chloramphenicol, erythromycin, lincomycin and gemifloxacin. However, synergistic interaction was observed with amoxicillin, ampicillin and ciprofloxacin. Superoxide anion content of Escherichia coli exposed to antibiotics with/without 2-(2-nitrovinyl) furan increased significantly (pâ¯<â¯.05). Furthermore, reduced glutathione decreased significantly with a corresponding increase in glutathione disulphide. In addition, malondialdehyde, a product of lipid peroxidation, increased significantly in E. coli exposed to antibiotics and 2-(2-nitrovinyl) furan. It can be deduced from this study that 2-(2-nitrovinyl) furan enhanced bacteriostatic and bactericidal antibiotics-mediated bacterial death possibly by potentiating reactive oxygen species generation and oxidative stress.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Compuestos de Vinilo
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Estrés Oxidativo
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Interacciones Farmacológicas
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Escherichia coli
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Furanos
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Antibacterianos
Idioma:
En
Revista:
Microb Pathog
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Año:
2018
Tipo del documento:
Article