Efficacy of phloroglucinol for treatment of abdominal pain: a systematic review of literature and meta-analysis of randomised controlled trials versus placebo.
Eur J Clin Pharmacol
; 74(5): 541-548, 2018 May.
Article
en En
| MEDLINE
| ID: mdl-29350249
ABSTRACT
AIM:
Phloroglucinol is a musculotropic anti-spasmodic drug. It is frequently prescribed in many European countries with a considerable cost for health services. The purpose of this study was to review the existing randomised controlled trials (RCT) comparing the efficacy of phloroglucinol treating abdominal pain versus placebo.METHODS:
A literature search was carried out up to May 2017 to select RCT comparing the effect of phloroglucinol versus placebo with intensity of abdominal pain as an endpoint. Studies concerning obstetric or gynaecologic-related pain were not included.RESULTS:
Three RCT were included and then analysed for risk of bias and meta-analysed. Only one RCT found that phloroglucinol was superior to placebo, although with a high risk of bias. The meta-analysis found a risk ratio of 1.10 (95% CI 0.95, 1.27) with no statistical significance.DISCUSSION:
There is insufficient data to justify the wide-spread prescription of phloroglucinol for alleviating abdominal pain.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Parasimpatolíticos
/
Floroglucinol
/
Dolor Abdominal
Tipo de estudio:
Clinical_trials
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Eur J Clin Pharmacol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia