Novel volumetric adsorptive microsampling technique for determination of perfluorinated compounds in blood.
Anal Biochem
; 545: 49-53, 2018 03 15.
Article
en En
| MEDLINE
| ID: mdl-29366694
ABSTRACT
Microsampling is an attractive option for significantly reducing the volume of blood taken for chemical analysis allowing for blood samples taken as a 'finger-prick' with a lancet. A novel, volumetric adsorptive microsampling (VAMS™) device, which reproducibly collects a small volume of 10⯵L whole blood in a hematocrit-independent manner, is evaluated in a human biomonitoring setting, and has been utilized for analysis of several perfluoroalkyl acids (PFAA). The results show that the VAMS technique is applicable for PFAA analysis, method has good linearity, repeatability, accuracy and is sufficiently sensitive for samples from general populations. The stability of PFAAs with VAMS devices is shown to be acceptable, which supports the sampling and transportation strategy of several study designs. Furthermore, as well as allowing for a quick and efficient extraction and analysis flow path, the VAMS microsampler is an easy to use device in a real-world sample collection scenario.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Recolección de Muestras de Sangre
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Técnicas Electroquímicas
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Pruebas con Sangre Seca
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Fluorocarburos
Límite:
Adolescent
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Adult
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Child
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Child, preschool
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Humans
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Middle aged
Idioma:
En
Revista:
Anal Biochem
Año:
2018
Tipo del documento:
Article