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Fatty acid binding protein deletion prevents stress-induced preference for cocaine and dampens stress-induced corticosterone levels.
Hamilton, John; Marion, Matthew; Figueiredo, Antonio; Clavin, Brendan H; Deutsch, Dale; Kaczocha, Martin; Haj-Dahmane, Samir; Thanos, Panayotis K.
Afiliación
  • Hamilton J; Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Research Institute on Addictions, University at Buffalo, Buffalo, New York.
  • Marion M; Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Research Institute on Addictions, University at Buffalo, Buffalo, New York.
  • Figueiredo A; Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Research Institute on Addictions, University at Buffalo, Buffalo, New York.
  • Clavin BH; Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Research Institute on Addictions, University at Buffalo, Buffalo, New York.
  • Deutsch D; Department of Biochemistry, Stony Brook University, Stony Brook, New York.
  • Kaczocha M; Department of Anesthesiology, Stony Brook University, Stony Brook, New York.
  • Haj-Dahmane S; Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Research Institute on Addictions, University at Buffalo, Buffalo, New York.
  • Thanos PK; Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Research Institute on Addictions, University at Buffalo, Buffalo, New York.
Synapse ; 72(6): e22031, 2018 06.
Article en En | MEDLINE | ID: mdl-29457656
ABSTRACT
Genetic and pharmacological manipulation of endocannabinoid (eCB) signaling has previously been shown to have an important role on the rewarding properties of drugs of abuse, including cocaine. Recently, fatty acid binding proteins (FABPs) have been proposed as intracellular transporters of the endocannabinoid anandamide (AEA) as well as other bioactive lipids to their catabolic enzyme, fatty acid amide hydrolase (FAAH). The role of these transporters in modulating the brains reward system has yet to be investigated. This study examined the effects of genetic deletion of FABP 5/7 on cocaine preference, as assessed by the Conditioned Place Preference (CPP) paradigm. Male and female wild type (WT) and FABP 5/7 KO mice showed similar acquisition of cocaine CPP, with no differences found in overall locomotor activity. In addition, while male and female WT mice showed stress-induced CPP for cocaine, male and female FABP 5/7 KO mice failed to show a stress-induced preference for the cocaine-paired chamber. Additionally, serum corticosterone levels were analyzed to explore any potential differences in stress response that may be responsible for the lack of stress-induced preference for cocaine. Serum samples were obtained in animals under basal conditions as well as following a 30-min tube restraint stress. Male and female FABP 5/7 KO mice showed reduced corticosterone levels under stress compared to their WT counterparts. The reduction in corticosterone response under stress may mediate that lack of a stress-induced preference for cocaine in the FABP 5/7 KO mice. Thus, the role of FABPs may play an important role in drug-seeking behavior under stressful conditions.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Estrés Psicológico / Corticosterona / Cocaína / Proteínas de Unión a Ácidos Grasos / Comportamiento de Búsqueda de Drogas / Proteína de Unión a los Ácidos Grasos 7 / Proteínas de Neoplasias Límite: Animals Idioma: En Revista: Synapse Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Estrés Psicológico / Corticosterona / Cocaína / Proteínas de Unión a Ácidos Grasos / Comportamiento de Búsqueda de Drogas / Proteína de Unión a los Ácidos Grasos 7 / Proteínas de Neoplasias Límite: Animals Idioma: En Revista: Synapse Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article