Your browser doesn't support javascript.
loading
Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells.
Wei, Xin; Dai, Zhi; Yang, Jing; Khan, Afsar; Yu, Hao-Fei; Zhao, Yun-Li; Wang, Yi-Fen; Liu, Ya-Ping; Yang, Zi-Feng; Huang, Wan-Yi; Wang, Xin-Hua; Zhao, Xu-Dong; Luo, Xiao-Dong.
Afiliación
  • Wei X; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
  • Dai Z; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's R
  • Yang J; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
  • Khan A; Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
  • Yu HF; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
  • Zhao YL; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
  • Wang YF; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
  • Liu YP; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
  • Yang ZF; Guangzhou Medical University, Guangzhou 511436, People's Republic of China.
  • Huang WY; Guangzhou Medical University, Guangzhou 511436, People's Republic of China.
  • Wang XH; Guangzhou Medical University, Guangzhou 511436, People's Republic of China. Electronic address: xinhuaw@gzhmu.edu.cn.
  • Zhao XD; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, People's Republic of China. Electronic address: zhaoxudong@mail.kiz.ac.cn.
  • Luo XD; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; Guangzhou Medical University, Guangzhou 511436, People's Republic of China. Electronic address: xdluo@mail.kib.ac.cn.
Bioorg Med Chem ; 26(8): 1776-1783, 2018 05 01.
Article en En | MEDLINE | ID: mdl-29486949
ABSTRACT
Unlike reported bisindoles linked by single bond directly, alstoniasidines A (1) and B (2), from Alstonia scholaris featuring unprecedented skeleton with two indole moieties bridged by a sugar, represented a novel bisindole type having strictosamide-glucopyranose-picraline scaffold. Both compounds exhibited selective cytotoxicity against human glioma stem cells (GSCs) and induced caspase-3 dependent extrinsic apoptosis by increasing the expression of interleukin 1 (IL-1), tumor necrosis factor (TNF-α), and the cleaved caspase-3, while damaged the unlimited proliferation and self-renewal capacity of GSCs. This finding might provide new type of leads for the selective killing of human glioma stem cells.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Alstonia / Azúcares / Glioma / Indoles / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Alstonia / Azúcares / Glioma / Indoles / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article