Palladium(II)-Catalyzed Mono- and Bis-alkenylation of N-Acetyl-2-aminobiaryls through Regioselective C-H Bond Activation.

Annamalai, Pratheepkumar; Hsu, Kou-Chi; Raju, Selvam; Hsiao, Huan-Chang; Chou, Chih-Wei; Lin, Gu-Ying; Hsieh, Cheng-Ming; Chen, Pei-Ling; Liu, Yi-Hung; Chuang, Shih-Ching

Annamalai, Pratheepkumar; Hsu, Kou-Chi; Raju, Selvam; Hsiao, Huan-Chang; Chou, Chih-Wei; Lin, Gu-Ying; Hsieh, Cheng-Ming; Chen, Pei-Ling; Liu, Yi-Hung; Chuang, Shih-Ching.

Afiliación

Annamalai P; Department of Applied Chemistry , National Chiao Tung University , Hsinchu 30013 , Taiwan.
Hsu KC; Department of Applied Chemistry , National Chiao Tung University , Hsinchu 30013 , Taiwan.
Raju S; Department of Applied Chemistry , National Chiao Tung University , Hsinchu 30013 , Taiwan.
Hsiao HC; Department of Applied Chemistry , National Chiao Tung University , Hsinchu 30013 , Taiwan.
Chou CW; Department of Applied Chemistry , National Chiao Tung University , Hsinchu 30013 , Taiwan.
Lin GY; Department of Applied Chemistry , National Chiao Tung University , Hsinchu 30013 , Taiwan.
Hsieh CM; Department of Applied Chemistry , National Chiao Tung University , Hsinchu 30013 , Taiwan.
Chen PL; Department of Chemistry , National Tsing Hua University , Hsinchu , Taiwan 30013.
Liu YH; Instrumentation Center , National Taiwan University , Taipei , Taiwan 30010.
Chuang SC; Department of Applied Chemistry , National Chiao Tung University , Hsinchu 30013 , Taiwan.

J Org Chem ; 83(7): 3840-3856, 2018 04 06.

Article en En | MEDLINE | ID: mdl-29521504

RESUMEN

We developed palladium-catalyzed oxidative coupling of olefins with N-acyl 2-aminobiaryls through a sequence of ortho C-H bond activation/alkene insertion/reductive elimination. Furthermore, we controlled the selectivity of mono- and bis-alkenylation products with the solvent effect. The developed protocol was promising for a broad substrate scope ranging from activated olefins with a wide variety of functional groups to unactivated olefins.

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2018 Tipo del documento: Article País de afiliación: Taiwán