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Effect of hepatitis B virus on steatosis in hepatitis C virus co-infected subjects: A multi-centre study and systematic review.
Goossens, N; de Vito, C; Mangia, A; Clément, S; Cenderello, G; Barrera, F; D'Ambrosio, R; Coppola, N; Zampino, R; Stanzione, M; Adinolfi, L E; Wedemeyer, H; Semmo, N; Müllhaupt, B; Semela, D; Malinverni, R; Moradpour, D; Heim, M; Trincucci, G; Rubbia-Brandt, L; Negro, F.
Afiliación
  • Goossens N; Division of Gastroenterology and Hepatology, Geneva University Hospitals, Geneva, Switzerland.
  • de Vito C; Division of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland.
  • Mangia A; Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy.
  • Clément S; Division of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland.
  • Cenderello G; Division of Infectious Diseases, Galliera Hospital, Genova, Italy.
  • Barrera F; Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, NSW, Australia.
  • D'Ambrosio R; Division of Gastroenterology and Hepatology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, Italy.
  • Coppola N; Department of Mental Health and Preventive Medicine, Second University of Naples, Napoli, Italy.
  • Zampino R; Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Napoli, Italy.
  • Stanzione M; Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Napoli, Italy.
  • Adinolfi LE; Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Napoli, Italy.
  • Wedemeyer H; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Semmo N; German Center for Infectious Disease Research, Hannover-Braunschweig, Germany.
  • Müllhaupt B; Hepatology, Department of Clinical Research, University of Bern, Bern, Switzerland.
  • Semela D; Division of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.
  • Malinverni R; Division of Gastroenterology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
  • Moradpour D; Hôpital Neuchâtelois, Neuchâtel, Switzerland.
  • Heim M; Division of Gastroenterology and Hepatology, University Hospital Lausanne, Lausanne, Switzerland.
  • Trincucci G; Division of Gastroenterology and Hepatology, University Hospital Basel, Basel, Switzerland.
  • Rubbia-Brandt L; Department of Pathology and Immunology, Geneva University, Geneva, Switzerland.
  • Negro F; Division of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland.
J Viral Hepat ; 25(8): 920-929, 2018 08.
Article en En | MEDLINE | ID: mdl-29532619
It remains unclear whether hepatitis B virus (HBV) infection may modify the severity of viral steatosis in patients coinfected with chronic hepatitis C virus (HCV). We examined the influence of coinfection with HBV on prevalence of steatosis in chronic hepatitis C in a multi-centre cohort of HBV-HCV subjects, and by performing a systematic review and meta-analysis of the literature. We centrally and blindly assessed steatosis prevalence and severity in a cohort of HBV-HCV coinfected subjects compared to HCV and HBV monoinfected controls and we performed a systematic review of studies addressing the prevalence of steatosis in HBV-HCV subjects compared to HCV controls. In the clinical cohort, we included 85 HBV-HCV, 69 HBV and 112 HCV subjects from 16 international centres. There was no significant difference in steatosis prevalence between the HBV-HCV and the HCV groups (33% vs 45%, P = .11). In subgroup analysis, lean HBV-HCV subjects with detectable HBV DNA had less steatosis than lean HCV subjects matched for HCV viremia (15% vs 45%, P = .02). Our literature search identified 5 additional studies included in a systematic review. Overall, prevalence of steatosis > 5% was similar in HBV-HCV infection compared to HCV (pooled odds ratio [OR] 0.91, 95% CI 0.53-1.6) although there was significant heterogeneity (I2 69%, P = .007). In conclusion, although the prevalence of steatosis is similar in HBV-HCV compared to HCV subjects, our analysis suggests that there may be an inhibitory effect of HCV-induced steatogenesis by HBV in certain subgroups of patients.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Hepatitis B Crónica / Hepatitis C Crónica / Hígado Graso / Coinfección Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Viral Hepat Asunto de la revista: GASTROENTEROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Suiza

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Hepatitis B Crónica / Hepatitis C Crónica / Hígado Graso / Coinfección Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Viral Hepat Asunto de la revista: GASTROENTEROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Suiza