Role of Wnt signaling during inflammation and sepsis: A review of the literature.
Int J Artif Organs
; 41(5): 247-253, 2018 May.
Article
en En
| MEDLINE
| ID: mdl-29562813
ABSTRACT
Despite the development of modern intensive care and new antimicrobial agents, the mortality of patients with severe sepsis and septic shock remains high. Systemic inflammation is a consequence of activation of the innate immune system. It is characterized by the intravascular release of proinflammatory cytokines and other vasoactive mediators, with concurrent activation of innate immune cells. The Wnt signaling pathway plays a critical role in the development of multicellular organisms. Abnormal Wnt signaling has been associated with many human diseases, ranging from inflammation and degenerative diseases to cancer. This article reviews the accumulating evidence that the Wnt signaling pathway plays a distinct role in inflammation and sepsis.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Citocinas
/
Sepsis
/
Vía de Señalización Wnt
/
Inflamación
Límite:
Humans
Idioma:
En
Revista:
Int J Artif Organs
Año:
2018
Tipo del documento:
Article
País de afiliación:
Alemania