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Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas.
Meghani, Khyati; Fuchs, Walker; Detappe, Alexandre; Drané, Pascal; Gogola, Ewa; Rottenberg, Sven; Jonkers, Jos; Matulonis, Ursula; Swisher, Elizabeth M; Konstantinopoulos, Panagiotis A; Chowdhury, Dipanjan.
Afiliación
  • Meghani K; Department of Radiation Oncology, Division of Radiation and Genome Stability, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Fuchs W; Department of Radiation Oncology, Division of Radiation and Genome Stability, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Detappe A; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Drané P; Department of Radiation Oncology, Division of Radiation and Genome Stability, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Gogola E; Division of Molecular Pathology and Cancer Genomics Netherlands, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
  • Rottenberg S; Division of Molecular Pathology and Cancer Genomics Netherlands, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Laenggassstr. 122, 3012 Bern, Switzerland.
  • Jonkers J; Division of Molecular Pathology and Cancer Genomics Netherlands, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
  • Matulonis U; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Swisher EM; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
  • Konstantinopoulos PA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address: panagiotis_konstantinopoulos@dfci.harvard.edu.
  • Chowdhury D; Department of Radiation Oncology, Division of Radiation and Genome Stability, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address: dipanjan_chowdhury@dfci.harvard.edu.
Cell Rep ; 23(1): 100-111, 2018 04 03.
Article en En | MEDLINE | ID: mdl-29617652
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Carcinoma / Cisplatino / Resistencia a Antineoplásicos / MicroARNs / Inestabilidad Genómica / Inhibidores de Poli(ADP-Ribosa) Polimerasas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Cell Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Carcinoma / Cisplatino / Resistencia a Antineoplásicos / MicroARNs / Inestabilidad Genómica / Inhibidores de Poli(ADP-Ribosa) Polimerasas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Cell Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos