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Fibulin-3 immunoexpression in malignant mesothelioma due to fluoro-edenite: a preliminary report.
Caltabiano, Rosario; Loreto, Carla; Vitale, Ermanno; Matera, Serena; Miozzi, Edoardo; Migliore, Marcello; Angelico, Giuseppe; Tumino, Rosario; Ledda, Caterina; Rapisarda, Venerando.
Afiliación
  • Caltabiano R; Department 'G.F. Ingrassia', Section of Anatomic Pathology, University of Catania, Catania, Italy.
  • Loreto C; Department of Biomedical & Biotechnological Sciences, Section of Anatomy & Histology, University of Catania, Catania, Italy.
  • Vitale E; Occupational Medicine, Department of Clinical & Experimental Medicine, University of Catania, Catania, Italy.
  • Matera S; Occupational Medicine, Department of Clinical & Experimental Medicine, University of Catania, Catania, Italy.
  • Miozzi E; Occupational Medicine, Department of Clinical & Experimental Medicine, University of Catania, Catania, Italy.
  • Migliore M; Academic Thoracic Surgery Unit, University Hospital 'Policlinico-Vittorio Emanuele', Department of Surgery, University of Catania, Catania, Italy.
  • Angelico G; Department 'G.F. Ingrassia', Section of Anatomic Pathology, University of Catania, Catania, Italy.
  • Tumino R; Cancer Registry & Histopathology Department, 'Civic - M. P. Arezzo' Hospital, ASP Ragusa, Italy.
  • Ledda C; Occupational Medicine, Department of Clinical & Experimental Medicine, University of Catania, Catania, Italy.
  • Rapisarda V; Occupational Medicine, Department of Clinical & Experimental Medicine, University of Catania, Catania, Italy.
Future Oncol ; 14(6s): 53-57, 2018 Mar.
Article en En | MEDLINE | ID: mdl-29664355
ABSTRACT
An increased standardized incidence and mortality rate were reported due to malignant mesothelioma (MM) in Biancavilla. Environmental investigations showed the presence of an asbestiform fiber fluoro-edenite (FE). MM develops with a latency of 20-60 years from exposure and specific and sensitive biomarkers are urgently needed. For this purpose, we evaluated Fibulin-3 (Fb-3) immunoexpression in human cases of MM related to FE exposure and its prognostic role. Immunohistochemical analysis of Fb-3 was carried out in eight MM patients resident in Biancavilla and the analysis showed evidence of environmental exposure to FE fibers. Six MM cases (3 epithelioid and 3 biphasic) showed a high immunoexpression of Fb-3 in neoplastic cells with nuclear and cytoplasmic localization. One epithelioid and one biphasic subtype did not show Fb-3 immunostaining. The results demonstrate the implication of Fb-3 in MM due to FE exposure and may possibly suggest its potential role as a diagnostic and prognostic marker.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas de la Matriz Extracelular / Asbestos Anfíboles / Exposición a Riesgos Ambientales / Neoplasias Pulmonares / Mesotelioma Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Future Oncol Año: 2018 Tipo del documento: Article País de afiliación: Italia
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas de la Matriz Extracelular / Asbestos Anfíboles / Exposición a Riesgos Ambientales / Neoplasias Pulmonares / Mesotelioma Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Future Oncol Año: 2018 Tipo del documento: Article País de afiliación: Italia