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3α,19-Dihydroxyl-ent-pimara-8(14),15-diene, a new diterpenoid from the rhizomes of Ricinus communis.
Zhang, Sheng-Nan; Zeng, Jin; Tan, Ya-Nan; Ma, Rui-Jing; Zhang, Gui-Jie; Wang, Heng-Shan; Tan, Qin-Gang.
Afiliación
  • Zhang SN; a Pharmacy School , Guilin Medical University , Guilin 541004 , China.
  • Zeng J; a Pharmacy School , Guilin Medical University , Guilin 541004 , China.
  • Tan YN; a Pharmacy School , Guilin Medical University , Guilin 541004 , China.
  • Ma RJ; b School of Traditional Chinese Medicine , China Pharmaceutical University , Nanjing 211198 , China.
  • Zhang GJ; a Pharmacy School , Guilin Medical University , Guilin 541004 , China.
  • Wang HS; a Pharmacy School , Guilin Medical University , Guilin 541004 , China.
  • Tan QG; c State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , Guangxi Normal University , Guilin 541004 , China.
J Asian Nat Prod Res ; 21(6): 522-527, 2019 Jun.
Article en En | MEDLINE | ID: mdl-29665732
ABSTRACT
A new natural product, 3α,19-dihydroxyl-ent-pimara-8(14),15-diene (1), which possesses an α-orientation hydroxymethyl at C-4 and ∆8,14 groups, as well as eight known compounds, was isolated from the rhizomes of Ricinus communis. The structure of 1 was elucidated by extensive spectroscopic methods and its absolute configurations were confirmed by X-ray crystallographic analysis. The inhibitory rate of 1 against protein tyrosine phosphatase 1B (PTP1B) was 49.49% at the concentration of 6.58 × 10-5 mol/L.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ricinus / Diterpenos / Inhibidores Enzimáticos / Proteína Tirosina Fosfatasa no Receptora Tipo 1 Límite: Animals Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ricinus / Diterpenos / Inhibidores Enzimáticos / Proteína Tirosina Fosfatasa no Receptora Tipo 1 Límite: Animals Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: China