Tumor-treating fields as a fourth treating modality for glioblastoma: a meta-analysis.
Acta Neurochir (Wien)
; 160(6): 1167-1174, 2018 06.
Article
en En
| MEDLINE
| ID: mdl-29696502
ABSTRACT
BACKGROUND:
We aim to review the available literature on patients suffering from glioblastoma treated with tumor-treating fields (TTFields) plus radio chemotherapy or conventional radio chemotherapy alone, to compare the efficacy and safety of the two methods.METHODS:
A systematic literature search was performed in PubMed, Cochrane library, and Scopus databases, in accordance with the PRISMA guidelines. Six studies met the inclusion criteria incorporating 1806 patients for the qualitative analysis and 1769 for the quantitative analysis.RESULTS:
This study reveals increased median overall survival (weighted mean difference (WMD) 3.29 [95% confidence interval (CI) 2.37, 4.21]; p < 0.00001), survival at 1 year (odds ratio (OR) 1.81 [95% CI 1.41, 2.32]; p < 0.00001) and 2 years (OR 2.33 [95% CI 1.73, 3.14]; p < 0.00001), and median progression-free survival (WMD 2.35 [95% CI 1.76, 2.93]; p < 0.00001) along with progression-free survival at 6 months (WMD 6.86 [95% CI 5.91, 7.81]; p < 0.00001) for the patients treated with TTFields. Survival at 3 years was comparable between the two groups. TTFields were associated with fewer adverse events compared to chemotherapy along with similar incidence of skin irritation.CONCLUSIONS:
TTFields are a safe and efficient novel treatment modality. More randomized controlled studies, with longer follow-up, are necessary to further assess the clinical outcomes of TTFields.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
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Terapia por Estimulación Eléctrica
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Glioblastoma
Tipo de estudio:
Clinical_trials
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Guideline
/
Qualitative_research
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Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Acta Neurochir (Wien)
Año:
2018
Tipo del documento:
Article
País de afiliación:
Grecia