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Biodegradable Nanocomposite Antimicrobials for the Eradication of Multidrug-Resistant Bacterial Biofilms without Accumulated Resistance.
Landis, Ryan F; Li, Cheng-Hsuan; Gupta, Akash; Lee, Yi-Wei; Yazdani, Mahdieh; Ngernyuang, Nipaporn; Altinbasak, Ismail; Mansoor, Sanaa; Khichi, Muhammadaha A S; Sanyal, Amitav; Rotello, Vincent M.
Afiliación
  • Landis RF; Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States.
  • Li CH; Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States.
  • Gupta A; Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States.
  • Lee YW; Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States.
  • Yazdani M; Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States.
  • Ngernyuang N; Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States.
  • Altinbasak I; Chulabhorn International College of Medicine , Thammasat University , Pathum Thani 12120 , Thailand.
  • Mansoor S; Department of Chemistry , Bogazici University , Istanbul 34342 , Turkey.
  • Khichi MAS; Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States.
  • Sanyal A; Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States.
  • Rotello VM; Department of Chemistry , Bogazici University , Istanbul 34342 , Turkey.
J Am Chem Soc ; 140(19): 6176-6182, 2018 05 16.
Article en En | MEDLINE | ID: mdl-29709168
ABSTRACT
Infections caused by multidrug-resistant (MDR) bacteria are a rapidly growing threat to human health, in many cases exacerbated by their presence in biofilms. We report here a biocompatible oil-in-water cross-linked polymeric nanocomposite that degrades in the presence of physiologically relevant biomolecules. These degradable nanocomposites demonstrated broad-spectrum penetration and elimination of MDR bacteria, eliminating biofilms with no toxicity to cocultured mammalian fibroblast cells. Notably, serial passaging revealed that bacteria were unable to develop resistance toward these nanocomposites, highlighting the therapeutic promise of this platform.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Biopelículas / Farmacorresistencia Bacteriana Múltiple / Escherichia coli / Nanocompuestos / Antibacterianos Idioma: En Revista: J Am Chem Soc Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Biopelículas / Farmacorresistencia Bacteriana Múltiple / Escherichia coli / Nanocompuestos / Antibacterianos Idioma: En Revista: J Am Chem Soc Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos