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CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy.
Mosqueira, Diogo; Mannhardt, Ingra; Bhagwan, Jamie R; Lis-Slimak, Katarzyna; Katili, Puspita; Scott, Elizabeth; Hassan, Mustafa; Prondzynski, Maksymilian; Harmer, Stephen C; Tinker, Andrew; Smith, James G W; Carrier, Lucie; Williams, Philip M; Gaffney, Daniel; Eschenhagen, Thomas; Hansen, Arne; Denning, Chris.
Afiliación
  • Mosqueira D; Department of Stem Cell Biology, Centre of Biomolecular Sciences, University of Nottingham, UK.
  • Mannhardt I; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Bhagwan JR; Partner Site Hamburg/Kiel/Lübeck, DZHK (German Center for Cardiovascular Research), Hamburg, Germany.
  • Lis-Slimak K; Department of Stem Cell Biology, Centre of Biomolecular Sciences, University of Nottingham, UK.
  • Katili P; Department of Stem Cell Biology, Centre of Biomolecular Sciences, University of Nottingham, UK.
  • Scott E; Department of Stem Cell Biology, Centre of Biomolecular Sciences, University of Nottingham, UK.
  • Hassan M; Department of Stem Cell Biology, Centre of Biomolecular Sciences, University of Nottingham, UK.
  • Prondzynski M; The Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London, UK.
  • Harmer SC; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Tinker A; Partner Site Hamburg/Kiel/Lübeck, DZHK (German Center for Cardiovascular Research), Hamburg, Germany.
  • Smith JGW; The Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London, UK.
  • Carrier L; The Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London, UK.
  • Williams PM; Department of Stem Cell Biology, Centre of Biomolecular Sciences, University of Nottingham, UK.
  • Gaffney D; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Eschenhagen T; Partner Site Hamburg/Kiel/Lübeck, DZHK (German Center for Cardiovascular Research), Hamburg, Germany.
  • Hansen A; Molecular Therapeutics and Formulation. School of Pharmacy, University of Nottingham, UK.
  • Denning C; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Eur Heart J ; 39(43): 3879-3892, 2018 11 14.
Article en En | MEDLINE | ID: mdl-29741611
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Arritmias Cardíacas / Cardiomiopatía Hipertrófica / Miocitos Cardíacos / Células Madre Pluripotentes / Contracción Miocárdica Límite: Humans Idioma: En Revista: Eur Heart J Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Arritmias Cardíacas / Cardiomiopatía Hipertrófica / Miocitos Cardíacos / Células Madre Pluripotentes / Contracción Miocárdica Límite: Humans Idioma: En Revista: Eur Heart J Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido