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T Follicular Regulatory Cells and Antibody Responses in Transplantation.
Wallin, Elizabeth F.
Afiliación
  • Wallin EF; Transplant Research Immunology Group, Nuffield Department of Surgical Sciences, Level 6 John Radcliffe Hospital, Oxford.
Transplantation ; 102(10): 1614-1623, 2018 10.
Article en En | MEDLINE | ID: mdl-29757907
ABSTRACT
De novo donor-specific antibody (DSA) formation is a major problem in transplantation, and associated with long-term graft decline and loss as well as sensitization, limiting future transplant options. Forming high-affinity, long-lived antibody responses involves a process called the germinal center (GC) reaction, and requires interaction between several cell types, including GC B cells, T follicular helper (Tfh) and T follicular regulatory (Tfr) cells. T follicular regulatory cells are an essential component of the GC reaction, limiting its size and reducing nonspecific or self-reactive responses.An imbalance between helper function and regulatory function can lead to excessive antibody production. High proportions of Tfh cells have been associated with DSA formation in transplantation; therefore, Tfr cells are likely to play an important role in limiting DSA production. Understanding the signals that govern Tfr cell development and the balance between helper and regulatory function within the GC is key to understanding how these cells might be manipulated to reduce the risk of DSA development.This review discusses the development and function of Tfr cells and their relevance to transplantation. In particular how current and future immunosuppressive strategies might allow us to skew the ratio between Tfr and Tfh cells to increase or decrease the risk of de novo DSA formation.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trasplante / Linfocitos T Reguladores / Linfocitos T Colaboradores-Inductores / Rechazo de Injerto / Isoanticuerpos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Transplantation Año: 2018 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trasplante / Linfocitos T Reguladores / Linfocitos T Colaboradores-Inductores / Rechazo de Injerto / Isoanticuerpos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Transplantation Año: 2018 Tipo del documento: Article