[Design, synthesis, and biological evaluation of phenylpropenamides compounds as anti-platelet aggregation].
Yao Xue Xue Bao
; 52(1): 120-5, 2017 01.
Article
en Zh
| MEDLINE
| ID: mdl-29911807
ABSTRACT
Twenty phenylpropenamide analogs with structural novelty were designed and synthesized upon pharmacophore-combination strategy. The structures of target compounds were elucidated by IR, 1H NMR, 13C NMR and MS, and all the target compounds were biologically evaluated for the inhibitory activities of platelet aggregation induced by adenosine diphoshateï¼ADPï¼ andï¼AAï¼ arachidonic acid via Bron method. As a result, compounds 6b, 9b, 9d and 9h demonstrated potent inhibitory activity against platelet aggregation induced by AA. Meanwhile, compounds 6b, 6d, 6j, 9b and 9g exhibited significant suppression of platelet aggregation induced by ADP.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Inhibidores de Agregación Plaquetaria
/
Agregación Plaquetaria
/
Amidas
Límite:
Humans
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
2017
Tipo del documento:
Article