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Altering gain of the infralimbic-to-accumbens shell circuit alters economically dissociable decision-making algorithms.
Sweis, Brian M; Larson, Erin B; Redish, A David; Thomas, Mark J.
Afiliación
  • Sweis BM; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455.
  • Larson EB; Medical Scientist Training Program, University of Minnesota, Minneapolis, MN 55455.
  • Redish AD; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455.
  • Thomas MJ; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455.
Proc Natl Acad Sci U S A ; 115(27): E6347-E6355, 2018 07 03.
Article en En | MEDLINE | ID: mdl-29915034
The nucleus accumbens shell (NAcSh) is involved in reward valuation. Excitatory projections from infralimbic cortex (IL) to NAcSh undergo synaptic remodeling in rodent models of addiction and enable the extinction of disadvantageous behaviors. However, how the strength of synaptic transmission of the IL-NAcSh circuit affects decision-making information processing and reward valuation remains unknown, particularly because these processes can conflict within a given trial and particularly given recent data suggesting that decisions arise from separable information-processing algorithms. The approach of many neuromodulation studies is to disrupt information flow during on-going behaviors; however, this limits the interpretation of endogenous encoding of computational processes. Furthermore, many studies are limited by the use of simple behavioral tests of value which are unable to dissociate neurally distinct decision-making algorithms. We optogenetically altered the strength of synaptic transmission between glutamatergic IL-NAcSh projections in mice trained on a neuroeconomic task capable of separating multiple valuation processes. We found that induction of long-term depression in these synapses produced lasting changes in foraging processes without disrupting deliberative processes. Mice displayed inflated reevaluations to stay when deciding whether to abandon continued reward-seeking investments but displayed no changes during initial commitment decisions. We also developed an ensemble-level measure of circuit-specific plasticity that revealed individual differences in foraging valuation tendencies. Our results demonstrate that alterations in projection-specific synaptic strength between the IL and the NAcSh are capable of augmenting self-control economic valuations within a particular decision-making modality and suggest that the valuation mechanisms for these multiple decision-making modalities arise from different circuits.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sinapsis / Algoritmos / Transmisión Sináptica / Toma de Decisiones / Sistema Límbico / Núcleo Accumbens Tipo de estudio: Health_economic_evaluation / Prognostic_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sinapsis / Algoritmos / Transmisión Sináptica / Toma de Decisiones / Sistema Límbico / Núcleo Accumbens Tipo de estudio: Health_economic_evaluation / Prognostic_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article