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Enhancing Oral Bioavailability of Cyclic RGD Hexa-peptides by the Lipophilic Prodrug Charge Masking Approach: Redirection of Peptide Intestinal Permeability from a Paracellular to Transcellular Pathway.
Schumacher-Klinger, Adi; Fanous, Joseph; Merzbach, Shira; Weinmüller, Michael; Reichart, Florian; Räder, Andreas F B; Gitlin-Domagalska, Agata; Gilon, Chaim; Kessler, Horst; Hoffman, Amnon.
Afiliación
  • Schumacher-Klinger A; Institute for Drug Research, School of Pharmacy, Faculty of Medicine , The Hebrew University of Jerusalem , P.O. Box 12065, Jerusalem 91120 , Israel.
  • Fanous J; Institute for Drug Research, School of Pharmacy, Faculty of Medicine , The Hebrew University of Jerusalem , P.O. Box 12065, Jerusalem 91120 , Israel.
  • Merzbach S; Institute for Drug Research, School of Pharmacy, Faculty of Medicine , The Hebrew University of Jerusalem , P.O. Box 12065, Jerusalem 91120 , Israel.
  • Weinmüller M; Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie , Technische Universität München , Lichtenbergstrasse 4 , 85748 Garching , Germany.
  • Reichart F; Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie , Technische Universität München , Lichtenbergstrasse 4 , 85748 Garching , Germany.
  • Räder AFB; Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie , Technische Universität München , Lichtenbergstrasse 4 , 85748 Garching , Germany.
  • Gitlin-Domagalska A; Institute of Chemistry , The Hebrew University of Jerusalem, Edmond Safra Campus, Givat Ram Campus, The Hebrew University , Jerusalem 91904 , Israel.
  • Gilon C; Institute of Chemistry , The Hebrew University of Jerusalem, Edmond Safra Campus, Givat Ram Campus, The Hebrew University , Jerusalem 91904 , Israel.
  • Kessler H; Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie , Technische Universität München , Lichtenbergstrasse 4 , 85748 Garching , Germany.
  • Hoffman A; Institute for Drug Research, School of Pharmacy, Faculty of Medicine , The Hebrew University of Jerusalem , P.O. Box 12065, Jerusalem 91120 , Israel.
Mol Pharm ; 15(8): 3468-3477, 2018 08 06.
Article en En | MEDLINE | ID: mdl-29976060
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptidos Cíclicos / Profármacos / Mucosa Intestinal Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Israel
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptidos Cíclicos / Profármacos / Mucosa Intestinal Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Israel