AgSbF<sub>6</sub>-Mediated Selective Thiolation and Selenylation at C-4 Position of Isoquinolin-1(2 H)-ones.

Zhu, You-Quan; He, Jing-Li; Niu, Yun-Xia; Kang, Hui-Ying; Han, Ting-Feng; Li, Hao-Yu

AgSbF₆-Mediated Selective Thiolation and Selenylation at C-4 Position of Isoquinolin-1(2 H)-ones.

Zhu, You-Quan; He, Jing-Li; Niu, Yun-Xia; Kang, Hui-Ying; Han, Ting-Feng; Li, Hao-Yu.

Afiliación

Zhu YQ; State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry , Nankai University , Tianjin 300071 , China.
He JL; State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry , Nankai University , Tianjin 300071 , China.
Niu YX; State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry , Nankai University , Tianjin 300071 , China.
Kang HY; State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry , Nankai University , Tianjin 300071 , China.
Han TF; State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry , Nankai University , Tianjin 300071 , China.
Li HY; State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry , Nankai University , Tianjin 300071 , China.

J Org Chem ; 83(17): 9958-9967, 2018 09 07.

Article en En | MEDLINE | ID: mdl-29993245

ABSTRACT

ABSTRACT

A new and facile AgSbF6-mediated protocol for the construction of C-4 thiolated or selenylated isoquinolin-1(2 H)-ones via a radical pathway was established. This reaction proceeded efficiently with excellent regioselectivity, a broad substrate scope, and good functional group tolerance. A radical reaction mechanism involving thiyl radicals as key intermediates is proposed for the present transformation.

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2018 Tipo del documento: Article País de afiliación: China