Geometry of Gene Expression Space of Wilms' Tumors From Human Patients.
Neoplasia
; 20(8): 871-881, 2018 08.
Article
en En
| MEDLINE
| ID: mdl-30029183
ABSTRACT
Wilms' tumor is a pediatric malignancy that is thought to originate from faulty kidney development during the embryonic stage. However, there is a large variation between tumors from different patients in both histology and gene expression that is not well characterized. Here we use a meta-analysis of published microarray datasets to show that Favorable Histology Wilms' Tumors (FHWT's) fill a triangle-shaped continuum in gene expression space of which the vertices represent three idealized "archetypes". We show that these archetypes have predominantly renal blastemal, stromal, and epithelial characteristics and that they correlate well with the three major lineages of the developing embryonic kidney. Moreover, we show that advanced stage tumors shift towards the renal blastemal archetype. These results illustrate the potential of this methodology for characterizing the cellular composition of Wilms' tumors and for assessing disease progression.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Expresión Génica
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Tumor de Wilms
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Neoplasias Renales
Tipo de estudio:
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Neoplasia
Asunto de la revista:
NEOPLASIAS
Año:
2018
Tipo del documento:
Article