FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and &#945;-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1.

Swiderska, Karolina Weronika; Szlachcic, Anna; Opalinski, Lukasz; Zakrzewska, Malgorzata; Otlewski, Jacek

FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1.

Swiderska, Karolina Weronika; Szlachcic, Anna; Opalinski, Lukasz; Zakrzewska, Malgorzata; Otlewski, Jacek.

Afiliación

Swiderska KW; Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland. karolina.weronika.swiderska@gmail.com.
Szlachcic A; Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland. anna.szlachcic@uwr.edu.pl.
Opalinski L; Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland. lukasz.opalinski@uwr.edu.pl.
Zakrzewska M; Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland. malgorzata.zakrzewska@uwr.edu.pl.
Otlewski J; Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland. jacek.otlewski@uwr.edu.pl.

Int J Mol Sci ; 19(7)2018 Jul 19.

Article en En | MEDLINE | ID: mdl-30029518

Asunto(s)

Alfa-Amanitina/farmacología; Factor 2 de Crecimiento de Fibroblastos/metabolismo; Oligopéptidos/farmacología; Receptor Tipo 1 de Factor de Crecimiento de Fibroblastos/metabolismo; Alfa-Amanitina/química; Animales; Línea Celular Tumoral; Endocitosis; Factor 2 de Crecimiento de Fibroblastos/química; Fibroblastos/efectos de los fármacos; Fibroblastos/metabolismo; Humanos; Lisosomas/efectos de los fármacos; Lisosomas/metabolismo; Ratones; Modelos Biológicos; Células 3T3 NIH; Oligopéptidos/química; Estructura Secundaria de Proteína; Transducción de Señal

Palabras clave

basic fibroblast growth factor; drug resistance; protein-drug conjugates; targeted cancer therapy

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oligopéptidos / Factor 2 de Crecimiento de Fibroblastos / Receptor Tipo 1 de Factor de Crecimiento de Fibroblastos / Alfa-Amanitina Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2018 Tipo del documento: Article País de afiliación: Polonia

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