Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID.

Sasaguri, Hiroki; Nagata, Kenichi; Sekiguchi, Misaki; Fujioka, Ryo; Matsuba, Yukio; Hashimoto, Shoko; Sato, Kaori; Kurup, Deepika; Yokota, Takanori; Saido, Takaomi C

Sasaguri, Hiroki; Nagata, Kenichi; Sekiguchi, Misaki; Fujioka, Ryo; Matsuba, Yukio; Hashimoto, Shoko; Sato, Kaori; Kurup, Deepika; Yokota, Takanori; Saido, Takaomi C.

Afiliación

Sasaguri H; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako-shi, Saitama, 351-0198, Japan. hiroki.sasaguri@riken.jp.
Nagata K; Department of Neurology and Neurological Science, Graduate School of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8510, Japan. hiroki.sasaguri@riken.jp.
Sekiguchi M; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako-shi, Saitama, 351-0198, Japan.
Fujioka R; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako-shi, Saitama, 351-0198, Japan.
Matsuba Y; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako-shi, Saitama, 351-0198, Japan.
Hashimoto S; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako-shi, Saitama, 351-0198, Japan.
Sato K; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako-shi, Saitama, 351-0198, Japan.
Kurup D; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako-shi, Saitama, 351-0198, Japan.
Yokota T; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako-shi, Saitama, 351-0198, Japan.
Saido TC; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, 02138, USA.

Nat Commun ; 9(1): 2892, 2018 07 24.

Article en En | MEDLINE | ID: mdl-30042426

Asunto(s)

Emparejamiento Base/genética; Sistemas CRISPR-Cas; Citidina Desaminasa/genética; Edición Génica/métodos; Mutación; Presenilina-1/genética; Animales; Secuencia de Bases; Citidina Desaminasa/metabolismo; Femenino; Masculino; Ratones Endogámicos C57BL; Ratones Endogámicos ICR; Ratones Noqueados; Presenilina-1/metabolismo; Reproducibilidad de los Resultados; Homología de Secuencia de Ácido Nucleico

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Emparejamiento Base / Citidina Desaminasa / Presenilina-1 / Sistemas CRISPR-Cas / Edición Génica / Mutación Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Japón

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