Your browser doesn't support javascript.
loading
A genome scan of diversifying selection in Ophiocordyceps zombie-ant fungi suggests a role for enterotoxins in co-evolution and host specificity.
Kobmoo, Noppol; Wichadakul, Duangdao; Arnamnart, Nuntanat; Rodríguez De La Vega, Ricardo C; Luangsa-Ard, Janet J; Giraud, Tatiana.
Afiliación
  • Kobmoo N; Ecologie Systématique Evolution, Université Paris-Sud, CNRS, AgroParisTech, Université Paris-Saclay, Orsay, France.
  • Wichadakul D; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Development Agency (NSTDA), Klhong Luang, Thailand.
  • Arnamnart N; Chulalongkorn University Big Data Analytics and IoT Center (CUBIC), Department of Computer Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand.
  • Rodríguez De La Vega RC; Center of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Luangsa-Ard JJ; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Development Agency (NSTDA), Klhong Luang, Thailand.
  • Giraud T; Ecologie Systématique Evolution, Université Paris-Sud, CNRS, AgroParisTech, Université Paris-Saclay, Orsay, France.
Mol Ecol ; 27(18): 3582-3598, 2018 09.
Article en En | MEDLINE | ID: mdl-30052297
ABSTRACT
Identification of the genes underlying adaptation sheds light on the biological functions targeted by natural selection. Searches for footprints of positive selection, in the form of rapid amino acid substitutions, and the identification of species-specific genes have proved to be powerful approaches to identifying the genes involved in host specialization in plant-pathogenic fungi. We used an evolutionary comparative genomic approach to identify genes underlying host adaptation in the ant-infecting genus Ophiocordyceps, which manipulates ant behaviour. A comparison of the predicted genes in the genomes of species from three species complexes-O. unilateralis, O. australis and O. subramanianii-revealed an enrichment in pathogenesis-associated functions, including heat-labile enterotoxins, among species-specific genes. Furthermore, these genes were overrepresented among those displaying significant footprints of positive selection. Other categories of genes suspected to be important for virulence and pathogenicity in entomopathogenic fungi (e.g., chitinases, lipases, proteases, core secondary metabolism genes) were much less represented, although a few candidate genes were found to evolve under positive selection. An analysis including orthologs from other entomopathogenic fungi in a broader context showed that positive selection on enterotoxins was specific to the ant-infecting genus Ophiocordyceps. Together with previous studies reporting the overexpression of an enterotoxin during behavioural manipulation in diseased ants, our findings suggest that heat-labile enterotoxins are important effectors in host adaptation and co-evolution in the Ophiocordyceps entomopathogenic fungi.
Asunto(s)
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Hormigas / Selección Genética / Enterotoxinas / Especificidad del Huésped / Hypocreales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Ecol Asunto de la revista: BIOLOGIA MOLECULAR / SAUDE AMBIENTAL Año: 2018 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Hormigas / Selección Genética / Enterotoxinas / Especificidad del Huésped / Hypocreales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Ecol Asunto de la revista: BIOLOGIA MOLECULAR / SAUDE AMBIENTAL Año: 2018 Tipo del documento: Article País de afiliación: Francia