A genetic portrait of the South-Eastern Carpathians based on autosomal short tandem repeats loci used in forensics.
Am J Hum Biol
; 30(5): e23139, 2018 09.
Article
en En
| MEDLINE
| ID: mdl-30099799
ABSTRACT
OBJECTIVES:
This work aimed to describe the genetic landscape of the Balkan Peninsula, as revealed by STR markers commonly used in forensics and spatial methods specifically developed for genetic data.METHODS:
We generated and analyzed 16 short tandem repeats (STRs) autosomal genotypes in 287 subjects from ten administrative/geographical regions of Eastern Europe (Romania and the Republic of Moldova). We report estimates of the allele frequencies in these sub-populations, their fixation indexes, and use these results to complement previous spatial analyses of Southern Europe.RESULTS:
In seven out of ten analyzed regional samples the heterozygosity, averaged across loci, was lower than expected. The average Fis was 0.011. Among the 16 loci, five returned a significant fixation index Fst. The composite Fst across the 16 loci, among the 10 regional samples, was 0.00417, a figure twice as large as that obtained with the same markers across the entire Northern Mediterranean. The first spatial principal component (sPC1) returned the picture of a Central-European pattern of frequencies for the Carpathians, which extended to the Southern boundary of the Balkan Peninsula. However, the 8 alleles extracted by sPC1 returned a picture of a strong reduction of the migration rate in the Carpathian region, mostly between the inner locations.CONCLUSIONS:
Our results revealed an unexpected heterogeneity in the area. We believe that populations from some regions will require treatment as distinct entities when considered in forensic applications.
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Bases de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Repeticiones de Microsatélite
/
Frecuencia de los Genes
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Am J Hum Biol
Asunto de la revista:
BIOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Italia