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TGFß inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.
Bird, Thomas G; Müller, Miryam; Boulter, Luke; Vincent, David F; Ridgway, Rachel A; Lopez-Guadamillas, Elena; Lu, Wei-Yu; Jamieson, Thomas; Govaere, Olivier; Campbell, Andrew D; Ferreira-Gonzalez, Sofía; Cole, Alicia M; Hay, Trevor; Simpson, Kenneth J; Clark, William; Hedley, Ann; Clarke, Mairi; Gentaz, Pauline; Nixon, Colin; Bryce, Steven; Kiourtis, Christos; Sprangers, Joep; Nibbs, Robert J B; Van Rooijen, Nico; Bartholin, Laurent; McGreal, Steven R; Apte, Udayan; Barry, Simon T; Iredale, John P; Clarke, Alan R; Serrano, Manuel; Roskams, Tania A; Sansom, Owen J; Forbes, Stuart J.
Afiliación
  • Bird TG; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK. t.bird@beatson.gla.ac.uk.
  • Müller M; Medical Research Council (MRC) Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
  • Boulter L; MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH164TJ, UK.
  • Vincent DF; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  • Ridgway RA; Medical Research Council (MRC) Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
  • Lopez-Guadamillas E; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh EH4 2XU, UK.
  • Lu WY; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  • Jamieson T; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  • Govaere O; Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
  • Campbell AD; Medical Research Council (MRC) Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
  • Ferreira-Gonzalez S; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  • Cole AM; Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven, B-3000 Leuven, Belgium.
  • Hay T; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  • Simpson KJ; Medical Research Council (MRC) Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
  • Clark W; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  • Hedley A; School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.
  • Clarke M; Medical Research Council (MRC) Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
  • Gentaz P; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  • Nixon C; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  • Bryce S; Institute for Infection Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
  • Kiourtis C; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  • Sprangers J; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  • Nibbs RJB; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  • Van Rooijen N; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  • Bartholin L; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.
  • McGreal SR; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  • Apte U; Institute for Infection Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
  • Barry ST; Vrije Universiteit Medical Center, Department of Molecular Cell Biology, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands.
  • Iredale JP; Centre de Recherche en Cancérologie de Lyon, UMR INSERM 1052, CNRS 5286, Lyon I University UMR S 1052, 69373 Lyon Cedex 08, France.
  • Clarke AR; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.
  • Serrano M; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.
  • Roskams TA; Oncology, IMED Biotech Unit, AstraZeneca, Cambridge CB2 0AA, UK.
  • Sansom OJ; MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH164TJ, UK.
  • Forbes SJ; University of Bristol, Senate House, Tyndall Avenue, Bristol BS8 1TH, UK.
Sci Transl Med ; 10(454)2018 08 15.
Article en En | MEDLINE | ID: mdl-30111642
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Factor de Crecimiento Transformador beta / Senescencia Celular / Comunicación Paracrina / Hígado / Regeneración Hepática Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Factor de Crecimiento Transformador beta / Senescencia Celular / Comunicación Paracrina / Hígado / Regeneración Hepática Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido