Eutypellenoids Aâ»C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1.
Mar Drugs
; 16(8)2018 Aug 16.
Article
en En
| MEDLINE
| ID: mdl-30115869
ABSTRACT
Three new pimarane diterpenes, eutypellenoids Aâ»C (1â»3), together with a known compound, eutypenoid C (4), were isolated from the culture extract of Eutypella sp. D-1 derived from the Arctic region. Compounds 1â»3 possessed an uncommon tetrahydrofuran-fused pimarane diterpene skeleton. The structures of all compounds were determined by detailed spectroscopic analysis, electronic circular dichroism (ECD) analysis, as well as a comparison with the literature data. Antibacterial, antifungal, and cytotoxic activities of these compounds were evaluated. Compound 2 displayed antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC values of 8 and 8 µg/mL, respectively. Additionally, compound 2 showed antifungal activity against Candidaparapsilosis, Candida albicans, Candida glabrata, and Candida tropicalis with MIC values of 8, 8, 16, and 32 µg/mL, respectively. Furthermore, compound 2 exhibited moderate cytotoxic activity against HCT-116 cell line with IC50 value of 3.7 µM.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Xylariales
/
Abietanos
/
Diterpenos
Límite:
Humans
Idioma:
En
Revista:
Mar Drugs
Asunto de la revista:
BIOLOGIA
/
FARMACOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
China