Efficient Nose-to-Lung Aerosol Delivery with an Inline DPI Requiring Low Actuation Air Volume.
Pharm Res
; 35(10): 194, 2018 Aug 21.
Article
en En
| MEDLINE
| ID: mdl-30132207
ABSTRACT
PURPOSE:
To demonstrate efficient aerosol delivery through an in vitro nasal model using a dry powder inhaler (DPI) requiring low actuation air volumes (LV) applied during low-flow nasal cannula (LFNC) therapy.METHODS:
A previously developed LV-DPI was connected to a LFNC system with 4 mm diameter tubing. System connections and the nasal cannula interface were replaced with streamlined components. To simulate nasal respiration, an in vitro nasal model was connected to a downstream lung simulator that produced either passive or deep nasal respiration. Performance of a commercial mesh nebulizer system was also considered.RESULTS:
For the optimized system, steady state cannula emitted dose was 75% of the capsule loaded dose. With cyclic nasal breathing, delivery efficiency to the tracheal filter was 53-55% of the loaded dose, which was just under the design target of 60%. Compared with a commercially available mesh nebulizer, the optimal LV-DPI was 40-fold more efficient and 150 times faster in terms of delivering aerosol to the lungs.CONCLUSIONS:
The optimized LV-DPI system is capable of high efficiency lung delivery of powder aerosols through a challenging nasal cannula interface.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Rociadores Nasales
/
Inhaladores de Polvo Seco
Idioma:
En
Revista:
Pharm Res
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos