Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-&#914;/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization.

Paw, Milena; Wnuk, Dawid; Kadziolka, Dominika; Sek, Aleksandra; Lasota, Slawomir; Czyz, Jaroslaw; Madeja, Zbigniew; Michalik, Marta

Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization.

Paw, Milena; Wnuk, Dawid; Kadziolka, Dominika; Sek, Aleksandra; Lasota, Slawomir; Czyz, Jaroslaw; Madeja, Zbigniew; Michalik, Marta.

Afiliación

Paw M; Faculty of Biophysics, Biochemistry and Biotechnology, Department of Cell Biology, Jagiellonian University, Gronostajowa 7, 30-378 Kraków, Poland. milena.paw@uj.edu.pl.
Wnuk D; Faculty of Biophysics, Biochemistry and Biotechnology, Department of Cell Biology, Jagiellonian University, Gronostajowa 7, 30-378 Kraków, Poland. dawid.wnuk@doctoral.uj.edu.pl.
Kadziolka D; Faculty of Biophysics, Biochemistry and Biotechnology, Department of Cell Biology, Jagiellonian University, Gronostajowa 7, 30-378 Kraków, Poland. doominnika@o2.pl.
Sek A; Faculty of Biophysics, Biochemistry and Biotechnology, Department of Cell Biology, Jagiellonian University, Gronostajowa 7, 30-378 Kraków, Poland. aleksandra.sek@interia.pl.
Lasota S; Nencki Institute of Experimental Biology, Laboratory of Intracellular Ion Channels, 02-093 Warsaw, Poland. aleksandra.sek@interia.pl.
Czyz J; Faculty of Biophysics, Biochemistry and Biotechnology, Department of Cell Biology, Jagiellonian University, Gronostajowa 7, 30-378 Kraków, Poland. slawomir.lasota@uj.edu.pl.
Madeja Z; Faculty of Biophysics, Biochemistry and Biotechnology, Department of Cell Biology, Jagiellonian University, Gronostajowa 7, 30-378 Kraków, Poland. jarek.czyz@uj.edu.pl.
Michalik M; Faculty of Biophysics, Biochemistry and Biotechnology, Department of Cell Biology, Jagiellonian University, Gronostajowa 7, 30-378 Kraków, Poland. z.madeja@uj.edu.pl.

Int J Mol Sci ; 19(9)2018 Aug 29.

Article en En | MEDLINE | ID: mdl-30158495

Asunto(s)

Asma/metabolismo; Conexina 43/metabolismo; Fenofibrato/farmacología; Fibroblastos/metabolismo; Miofibroblastos/metabolismo; Proteína Smad2/metabolismo; Proteína smad3/metabolismo; Factor de Crecimiento Transformador beta/metabolismo; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Células Cultivadas; Fibroblastos/citología; Humanos; Miofibroblastos/citología; Transducción de Señal/efectos de los fármacos

Palabras clave

TGF-ß/Smad signaling; actin cytoskeleton architecture; bronchial asthma; connexin 43; fenofibrate; fibroblast-to-myofibroblast transition

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fenofibrato / Asma / Factor de Crecimiento Transformador beta / Conexina 43 / Proteína Smad2 / Proteína smad3 / Miofibroblastos / Fibroblastos Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2018 Tipo del documento: Article País de afiliación: Polonia

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google