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Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation.
Sheffels, Erin; Sealover, Nancy E; Wang, Chenyue; Kim, Do Hyung; Vazirani, Isabella A; Lee, Elizabeth; M Terrell, Elizabeth; Morrison, Deborah K; Luo, Ji; Kortum, Robert L.
Afiliación
  • Sheffels E; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
  • Sealover NE; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
  • Wang C; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
  • Kim DH; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
  • Vazirani IA; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
  • Lee E; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
  • M Terrell E; Laboratory of Cell and Developmental Signaling, National Cancer Institute (NCI)-Frederick, Frederick, MD 21702, USA.
  • Morrison DK; Laboratory of Cell and Developmental Signaling, National Cancer Institute (NCI)-Frederick, Frederick, MD 21702, USA.
  • Luo J; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD 20892, USA.
  • Kortum RL; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. robert.kortum@usuhs.edu.
Sci Signal ; 11(546)2018 09 04.
Article en En | MEDLINE | ID: mdl-30181243
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transformación Celular Neoplásica / Proteínas Proto-Oncogénicas p21(ras) / Proteínas Son Of Sevenless / Fibroblastos Límite: Animals / Humans Idioma: En Revista: Sci Signal Asunto de la revista: CIENCIA / FISIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transformación Celular Neoplásica / Proteínas Proto-Oncogénicas p21(ras) / Proteínas Son Of Sevenless / Fibroblastos Límite: Animals / Humans Idioma: En Revista: Sci Signal Asunto de la revista: CIENCIA / FISIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos