Your browser doesn't support javascript.
loading
Granulomatous dermatitis secondary to vemurafenib in a child with Langerhans cell histiocytosis.
Chen, Lily; Hsi, Andy C; Kothari, Alok; Dehner, Louis P; Hayashi, Robert J; Coughlin, Carrie C.
Afiliación
  • Chen L; School of Medicine, Washington University, St. Louis, Missouri.
  • Hsi AC; Department of Pathology, California Skin Institute, San Jose, California.
  • Kothari A; Lauren V. Ackerman Laboratory of Surgical Pathology and Dermatopathology Center, St. Louis Children's Hospital, Washington University Medical Center, St. Louis, Missouri.
  • Dehner LP; Division of Hematology/Oncology, Department of Pediatrics, School of Medicine, Washington University, St. Louis, Missouri.
  • Hayashi RJ; Lauren V. Ackerman Laboratory of Surgical Pathology and Dermatopathology Center, St. Louis Children's Hospital, Washington University Medical Center, St. Louis, Missouri.
  • Coughlin CC; Division of Hematology/Oncology, Department of Pediatrics, School of Medicine, Washington University, St. Louis, Missouri.
Pediatr Dermatol ; 35(6): e402-e403, 2018 Nov.
Article en En | MEDLINE | ID: mdl-30216522
ABSTRACT
We present a 3-year-old boy with Langerhans cell histiocytosis who developed granulomatous dermatitis while taking vemurafenib. Vemurafenib currently has Food and Drug Administration approval for the treatment of BRAF V600E+ metastatic melanoma in adults, but recent discoveries of BRAF V600E in more than half of tested Langerhans cell histiocytosis lesions have prompted clinical trials of vemurafenib therapy for children with refractory, multisystem Langerhans cell histiocytosis. This report contributes to the knowledge of its potential side effects when used in children.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sulfonamidas / Histiocitosis de Células de Langerhans / Erupciones por Medicamentos / Indoles / Antineoplásicos Tipo de estudio: Etiology_studies Límite: Child, preschool / Humans / Male Idioma: En Revista: Pediatr Dermatol Año: 2018 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sulfonamidas / Histiocitosis de Células de Langerhans / Erupciones por Medicamentos / Indoles / Antineoplásicos Tipo de estudio: Etiology_studies Límite: Child, preschool / Humans / Male Idioma: En Revista: Pediatr Dermatol Año: 2018 Tipo del documento: Article