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Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors.
Jiang, Jian-Kang; Huang, Xiuli; Shamim, Khalida; Patel, Paresma R; Lee, Arthur; Wang, Amy Q; Nguyen, Kimloan; Tawa, Gregory; Cuny, Gregory D; Yu, Paul B; Zheng, Wei; Xu, Xin; Sanderson, Philip; Huang, Wenwei.
Afiliación
  • Jiang JK; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA. Electronic address: jiankangj@mail.nih.gov.
  • Huang X; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
  • Shamim K; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
  • Patel PR; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
  • Lee A; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
  • Wang AQ; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
  • Nguyen K; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
  • Tawa G; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
  • Cuny GD; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 4849 Calhoun Road, Health Building 2, Room, 7036, Houston, TX 77204, USA.
  • Yu PB; Brigham and Women's Hospital and Harvard Medical School, Division of Cardiovascular Medicine, 20 Shattuck Street, Thorn Biosciences 1219, Boston, MA 02115, USA.
  • Zheng W; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
  • Xu X; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
  • Sanderson P; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA.
  • Huang W; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA. Electronic address: huangwe@mail.nih.gov.
Bioorg Med Chem Lett ; 28(20): 3356-3362, 2018 11 01.
Article en En | MEDLINE | ID: mdl-30227946
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Sulfonamidas / Receptores de Activinas Tipo I / Inhibidores de Proteínas Quinasas Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Sulfonamidas / Receptores de Activinas Tipo I / Inhibidores de Proteínas Quinasas Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article