Bromopyrrole Alkaloid Inhibitors of the Proteasome Isolated from a Dictyonella sp. Marine Sponge Collected at the Amazon River Mouth.
J Nat Prod
; 81(10): 2296-2300, 2018 10 26.
Article
en En
| MEDLINE
| ID: mdl-30281303
ABSTRACT
The new pyrrole-imidazole and pyrrole-guanidine alkaloids 4-debromooroidin (1), 4-debromougibohlin (2), 5-debromougibohlin (3), and 5-bromopalau'amine (4), along with the known hymenidin (5) and (+)-monobromoisophakellin (6), have been isolated from a Dictyonella sp. marine sponge, collected at the Amazon River mouth. The bromine-substitution pattern observed for compounds 1, 2 and 4 is unusual among bromopyrrole alkaloids isolated from marine sponges. The 20S proteasome inhibitory activities of compounds 1-6 have been recorded, with 5-bromopalau'amine (4) being the most active in this series.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Poríferos
/
Pirroles
/
Inhibidores de Proteasoma
Límite:
Animals
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
J Nat Prod
Año:
2018
Tipo del documento:
Article
País de afiliación:
Brasil